Brush teeth once daily. Depending on your dog’s preference, us the TripleFlex brush or the Fingertip brush. Squeeze a small amount of Advanced Whitening Brushing Gel onto the brush and allow your dog to taste. Reapply and gently brush in a circular motion. Never use human toothpaste, which can upset your pet’s stomach. For maximum effect, withhold food and water for 30 minutes before and after treatment.